Adrian Johnston is well known for his work at the intersection of Lacanian psychoanalysis, German idealism, contemporary French philosophy and most recently cognitive neuroscience. In the context of the current issue, Johnston represents the most complete development of a contemporary theory of Transcendental Materialism. In the following interview we explore both the implications of Johnston’s previous work, as well as the directions his most recent projects are taking.

This article explores the role of nature in two strands of contemporary materialist philosophy: new materialism, and transcendental materialism. Through an analysis of these strands of materialism via the work of Jane Bennett, William E. Connolly, Catherine Malabou, and Adrian Johnston, the article attempts to delineate these perspectives into the opposed camps of monist and dialectical materialisms. The implications of these differing materialist ontologies are then discussed in terms of the theorization of nature as either a vital material force (...) or as a weakness characterizing matter itself. After outlining the importance of nature for these two opposed theories, the lack of serious engagement with the work of F.W.J. Schelling by either group is discussed as a potential middle ground between the Spinozism of the new materialism and the Hegelianism of transcendental materialism, due to its large-scale political analysis, less pessimistic perspective towards the possibility of a contemporary humanism, and embrace of recent advances in the empirical sciences. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Many scholars and activists seek to eliminate “race”—the word and the concept—from our vocabulary. Their claim is clear: because science has shown that racial essentialism is false and because the idea of race has proved virulent, we should do away with the concept entirely. Michael O. Hardimon criticizes this line of thinking, arguing that we must recognize the real ways in which race exists in order to revise our understanding of its significance. Rethinking Race provides a novel answer to (...) the question “What is race?” Pernicious, traditional racialism maintains that people can be judged and ranked according to innate racial features. Hardimon points out that those who would eliminate race make the mistake of associating the word only with this view. He agrees that this concept should be jettisoned, but draws a distinction with three alternative ideas: first, a stripped-down version of the ordinary concept of race that recognizes minimal physical differences between races but does not consider them significant; second, a scientific understanding of populations with shared lines of descent; and third, an acknowledgment of “socialrace” as a separate construction. Hardimon provides a language for understanding the ways in which races do and do not exist. His account is realistic in recognizing the physical features of races, as well as the existence of races in our social world. But it is deflationary in rejecting the concept of hierarchical or defining racial characteristics. Ultimately, Rethinking Race offers a philosophical basis for repudiating racism without blinding ourselves to reality. (shrink)

This paper explores possible connections between gender and the willingness to engage in unethical business behavior. Two approaches to gender and ethics are presented: the structural approach and the socialization approach. Data from a sample of 213 business school students reveal that men are more than two times as likely as women to engage in actions regarded as unethical but it is also important to note that relatively few would engage in any of these actions with the exception of buying (...) stock with inside information. Fifty percent of the males were willing to buy stock with insider information. Overall, the results support the gender socialization approach. (shrink)

Argues that role obligations are not marginal, "that they are central to morality and should be taken seriously." "A 'role obligation' is a moral requirement, which attaches to an institutional role, whose content is fixed by the function of the role, and whose normative force flows from the role." Rejects what he calls the doctrine of perfect adequacy which holds that role obligations are both comprehensive and transparent. Although this may have been plausible at earlier times, it is clearly implausible (...) now. It is the implausibility of this doctrine which has led theorists to accept the standard view: which holds that role obligations that are noncontractual are extremely problematic. Once we reject the doctrine of perfect adequacy, however, we can see the significance of role obligations more clearly. [The content of role obligations, Hardimon admits, is indeterminate in the sense that it is subject to constructive interpretation. This suggests, however, that the obligations are not the source of their normative power, rather it is their justifying value which explains why some role requirements are obligatory. This is confirmed by the rest of the article.] One thing that should lead us to question the notion that we do not have obligations of this sort by considering what it would be like to have no noncontractual role obligations. [This, however, does not establish that the force of role obligations flows from the obligations themselves.] One objection to NCR obligations is that they may require acting in accordance with an unjust institution. However, the solution here is the same as with contractual obligations: unjust institutions and contracts do not bind. Moves on to identity. "What I am assuming is that most of us do at least tacitly conceive of ourselves as family members and citizens, that these self-understandings are central to our own general self-conception, and that we can, through reflection come to recognize that we do in fact conceive of ourselves in these ways. If this is correct, then abandoning the idea that we have noncontractual role obligations would require radical revision of our self-conception, for we cannot give up the idea of nonctractual role obligation without also ceasing to conceive of ourselves as family members and citizens. What, after all, would it mean to say that we conceive of ourselves as family members but regard oursleves as having no familial obligations whatsoever?...The upshot of the last two paragraphs is that the cost of abandoning our conception of ourselves as family members and citizens would be enormous." [The moral significance of identity is unclear here - is the only normative element loss of identity with rejection of role obligations? What of the case when one's identity is caught up in a role which requires one to act immorally in other ways?] If impressment is our concern, it shouldn't be, for role obligations are not like impressment - one is born into them, not impressed [how does this make a difference?]. Role must be reflectively acceptable to produce genuine obligations. "Determining whether a given social role is reflectively acceptable involves stepping back from that role in thought and asking whether it is a role people ought to occupy and play. Determining that a given social role is reflectively acceptable involves judging that it is meaningful, rational, or good." [Hence, some independent value is going to do all the work for role obligations - the normative force of a role does not flow from the role itself.] Concerning voluntary roles - even if we agree that voluntary acceptance is essential, this omits important elements of role identification. "The key component of the idea of identifying with a role is that of conceiving of oneself as someone for whom the norms, that is, the evaluative standards associated with a role, its rights, duties, virtues, ideals, and supererogations, have reason-giving force. Here is the idea. If you identify with a role, its norms will function for you as reasons. If you are a judge who identifies with the role of judge, the fact that this is something judges do will give you a reason for doing it." [Clearly a non-sequiter - conceiving of oneself as having a reason does not give oneself a reason for doing - there must actually be a reason for doing something. Moreover, the content of the role may be in question - and here we are to engage in constructive interpretation, which is just to say that we are to identify some underlying value and this will serve to justify and determine the content of the role. Refers to usage of "look, its your job" as basis for substantiating claims about the normative force of identity. "But here a basic point of similarity emerges between contractual and noncontractual role obligations. People can and do identify with their noncontractual roles and not just with their contractual roles. And when they do, assuming that the appropriate background moral conditions are in place, the fact taht they occupy these roles will provide them with reasons for carrying out the tasks of their noncontractual roles...The basic form of motivation provided by identification with contractual and noncontractual role obligations is the same.". (shrink)

This book provides an authoritative account of Hegel's social philosophy at a level that presupposes no specialised knowledge of the subject. Hegel's social theory is designed to reconcile the individual with the modern social world. Michael Hardimon explores the concept of reconciliation in detail and discusses Hegel's views on the relationship between individuality and social membership, and on the family, civil society, and the state. The book is an important addition to the string of major studies of Hegel published (...) by Cambridge. It will interest a broad swathe of readers in philosophy, (both students and specialists), and could be used in courses on political and social theory. -/- . (shrink)

The ordinary concept of race is important and poorly understood. The present article seeks to address this problem by providing a general answer to the question: What is the concept of race?

In the last few decades, several philosophers have written on the topic of moral revolutions, distinguishing them from other kinds of society-level moral change. This article surveys recent accounts of moral revolutions in moral philosophy. Different authors use quite different criteria to pick out moral revolutions. Features treated as relevant include radicality, depth or fundamentality, pervasiveness, novelty and particular causes. We also characterize the factors that have been proposed to cause moral revolutions, including anomalies in existing moral codes, changing honour (...) codes, art, economic conditions and individuals or groups. Finally, we discuss what accounts of moral revolutions have in common, how they differ and how moral revolutions are distinguished from other kinds of moral change, such as drift and reform. (shrink)

This article challenges the orthodox view that there is and can be no scientifically valid concept of race applicable to human beings by presenting a candidate scientific concept of biological race. The populationist concept of race specifies that a “race” is a subdivision of Homo sapiens—a group of populations that exhibits a distinctive pattern of genetically transmitted phenotypic characters and that belongs to an endogamous biological lineage initiated by a geographically separated and reproductively isolated founding population. The viability of the (...) PRC is shown by demonstrating its capacity to withstand a wide range of objections. A common theme is that the objections turn on misconceptions of the idea of a scientific concept of race. The final section argues that the PRC will not foster racism. (shrink)

The introduction of Western healthcare, via colonialism, into Africa facilitated a confrontation of indigenous and exogenous “medical” knowledge as well as the attendant praxis. Although colonialism has been expunged from the shores of Africa, the epistemic and ideological frictions it introduced into the sphere of healthcare linger and raise different dilemmas. Against this background, this paper explores pragmatic and ethical approaches that may help engage these tensions in the context of drug development based on validated traditional phytomedicines.

Do pharmaceutical companies have a moral obligation to expand access to investigational drugs to patients outside the clinical trial? One reason for thinking they do not is that expanded access programs might negatively affect the clinical trial process. This potential impact creates dilemmas for practitioners who nevertheless acknowledge some moral reason for expanding access. Bioethicists have explained these reasons in terms of beneficence, compassion, or a principle of rescue, but their arguments have been limited to questions of moral permissibility, leaving (...) for future research the question of whether expanded access is morally obligatory. We take up this further question and argue that pharmaceutical companies have a moral obligation to expand access. Our defense is not based on beneficence, compassion, or rescue, but instead on a reciprocal moral expectation resulting from existing social commitments that help ensure a robust pharmaceutical practice within the broader healthcare system. Our aim is to give this obligation, along with several others, a coherent and plausible structure within the wider clinical trial process so that one might better explain the sources of the dilemmas and their possible resolutions. (shrink)

Many drugs used in paediatric medicine are off-label. There is a rising call for the use of adaptive clinical trial designs in responding to the need for safe and effective drugs given their potential to offer efficiency and cost-effective benefits compared with traditional clinical trials. ADs have a strong appeal in paediatric clinical trials given the small number of available participants, limited understanding of age-related variability and the desire to limit exposure to futile or unsafe interventions. Although the ethical value (...) of adaptive trials has increasingly come under scrutiny, there is a paucity of literature on the ethical dilemmas that may be associated with paediatric adaptive designs. This paper highlights some of these ethical concerns around safety, scientific/social value and caregiver/guardian comprehension of the trial design. Against this background, the paper develops a non-static conceptual lens for understanding PADs. It shows that ADs are epistemically open and reduce some of the knowledge-associated uncertainties inherent in clinical trials as well as fast-track the time to draw conclusions about the value of evaluated drugs/treatments. On this note, the authors argue that PADs are ethically justifiable given they have multiple layers of safety, exposing enrolled children to lesser potential risks, create social/scientific value generally and for paediatric populations in particular, specifically foster the flourishing of paediatric populations and can significantly improve paediatric trial efficiency when properly designed and implemented. However, because PADs are relatively new and their regulatory, ethical and logistical characteristics are yet to be clarified in some jurisdictions, the cooperation of various public and private stakeholders is required to ensure that the interests of children, their caregivers and parents/guardians are best served while exposing paediatric research subjects to the most minimal of risks when they are enrolled in paediatric trials that use ADs. Data sharing not applicable as no datasets generated and/or analysed for this study. Not applicable. (shrink)

Explication of the concept of socialrace: the concept variously refers to (1) a social group that is taken to be a racialist race, (2) the social position occupied by a particular social group that is a socialrace and (3) the system of social positions that are socialraces. Socialrace is distinguished from other more familiar forms of social construction. The sense in which socialrace counts as a race concept is explained. The advantages of the term ‘socialrace’ are discussed. The desiderata for (...) a conception of socialrace are articulated. The concept socialrace is contrasted with other similar concepts. (shrink)

Where exactly did Hegel go wrong on race? Moellendorf helpfully tells us that Hegel's treatment of race begins systematically in the Philosophy of Subjective Spirit and that he went wrong philosophically in the use of the biological category of race. This is basically correct but requires precisification. This article considers why Hegel's category of race is not unambiguously biological. Race's biological status can be problematized from the standpoint of contemporary biology and from the standpoint of Hegel's system. The textual placement (...) of Hegel's systematic discussion of race in the philosophy of spirit makes clear that Hegel conceived of race in spiritual terms. Hegel took race to be a biospiritual category. Hegel was clearly committed to the now-controversial proposition that there is such a thing as human biological race, that there is a plurality of biological human races. He regarded race as a robust natural kind. His preferred list of races includes Caucasians, Negros, Mongolian, Malaysians and Americans. One noteworthy feature of his understanding of race's physical aspect was his focus on the formation of the skull and the face. At the same time, he clearly held that there were other deeper physical differences that accounted for the spiritual differences of race. Hegel was perfectly clear that race has a spiritual as well as physical aspect. He held that that the members of racial groups essentially shared certain fundamental, heritable, moral, intellectual and cultural characteristics with one another that they did not share with members of any other race and that these differences were such as to support an objective ranking. This shows that Hegel took the category of race to be the sort of category we today would characterize as ‘racialist’. Hegel's concept of race was the racialist concept of race. (shrink)

This essay presents four ways of thinking about race. They consist of four related but distinct race concepts: the racialist concept of race, which is the traditional, pernicious, essentialist, and hierarchical concept of race; the concept of socialrace, which is the antiracist concept of race as a social construction; the minimalist concept of race, which is the deflationary concept of biological race that represents race as a matter of color, shape and geographical ancestry; and the populationist concept of race, the (...) race concept that represents races as populations, deriving from geographically separated and reproductive isolated founding populations. Taken together, the four concepts can help us better navigate our way through the murky conceptual domain of “race.”. (shrink)

An introduction to the special issue on epistemic logic and the foundations of game theory edited by Michael Bacharach and Philippe Mongin. Contributors are Michael Bacharach, Robert Stalnaker, Salvatore Modica and Aldo Rustichini, Luc Lismont and Philippe Mongin, and Hyun-Song Shin and Timothy Williamson.

Volume 19, Issue 7, July 2019, Page 53-55.

The central aim of Hegel's' social philosophy (the Rechtsphilosophie) is to reconcile his contemporaries--the men and women of the nineteenth century--to the modern social world. By "the modem social world" I mean the central social institutions of that era: the family, civil society, and the state. Hegel seeks to enable his contemporaries to overcome their alienation from this world by providing them with a philosophical theory that will reveal its true nature (PR, Preface sec. 14). "The project of reconciliation" is (...) the name I have given to this enterprise. My aim in this article is to introduce Hegel's project. I shall neither attempt to present the project nor attempt to assess it. My aim is simply to explain what the project is. I begin by considering the problem the project addresses and the sort of solution it proposes, and devote the remainder of the article to an examination of the project's goal. (shrink)

Why do otherwise well-intentioned managers make decisions that have negative social or environmental consequences? To answer this question, the authors combine the literature on construal level theory with the compromise effect to explore the circumstances that lead to seemingly unethical decision-making. The results of two studies suggest that the degree to which managers make high-risk tradeoffs is highly influenced by how they mentally represent the decision context. The authors find that managers are more likely to make seemingly unethical tradeoffs when (...) psychological distance is high (rather than low) and when they are forced to choose between competing alternatives. However, when given the option not to choose, managers better reflect on the consequences of each alternative, and thus become more likely to choose options with less risk of negative consequences. The results suggest that simply offering managers the option not to choose may reduce psychological distance and help organizations avoid seemingly unethical decision-making. (shrink)

A shift in popular discourse over the last few years makes it makes it tempting to think that the answer to the question whether racism is essentially systemic is yes. My argument, however, is that there are forms of racism—things that are properly counted as instances of racism—that are distinct from and independent of systemic racism. These include ideational racism, ideological racism, racism as antipathy, and racism as prejudice and bigotry. Systemic racism does exist and is not reducible to these (...) other forms of racism. It is arguably the form of racism that should be of most concern to us, but it is not the only form that racism takes. (shrink)

Funding broadly connotes the notion of an institution and/or institutions making money and other resources available to individual researchers and organizations to accomplish specific projects. Whi...

This book offers an examination of the political and ontological significance of the authorship of Søren Kierkegaard in relation to German Idealism and contemporary European philosophy.

Throughout his career, Wittgenstein was preoccupied with issues in the philosophy of perception. Despite this, little attention has been paid to this aspect of Wittgenstein's work. This volume redresses this lack, by bringing together an international group of leading philosophers to focus on the impact of Wittgenstein's work on the philosophy of perception. The ten specially commissioned chapters draw on the complete range of Wittgenstein's writings, from his earliest to latest extant works, and combine both exegetical approaches with engagements with (...) contemporary philosophy of mind. Topics covered include: perception and judgement in the _Tractatus _ aspect-perception the putative intentionality of perception representationalism. The book also includes an overview which summarises the evolution of Wittgenstein's views on perception throughout his life. With an outstanding array of contributors, _Wittgenstein and Perception_ is essential reading for students and scholars of Wittgenstein’s work, as well as those working in philosophy of mind and philosophy of perception. Contributors: Yasuhiro Arahata, Michael Campbell, William Child, Daniel Hutto, Michael O’Sullivan, Marie McGinn, Michel terHark, Charles Travis, and José Zalabardo. (shrink)

The power of the scientific enterprise presents multiple avenues for harnessing and increasingly controlling biological phenomena and instituting interventions in different areas of biomedicine (Af...

Apoptosis (programmed cell death) is an evolutionarily conserved cellular process, important for development and homeostasis(1). Most apoptotic cells share a common set of morphological and physiological characteristics that distinguish them from necrotic deaths(2). While genetic studies have indicated that these characteristic changes result from the activation of an endogenous ‘suicide program’(3), little is known about the nature of this program and the molecular events underlying these changes. Two recent papers(4,5) describing cell‐free extracts that reproduce several of the characteristic changes observed (...) in apoptotic cells promise to make these phenomena accessible to biochemical analysis. (shrink)

In British Columbia, brown bears , black bears , and cougars must relate to growing human populations. This study examines age- and gender-related attitudes to these animals in the urbanizing, agriculturally significant, intermontane city of Kamloops. Most respondents, especially women, feared cougars and bears, saw bears as more troublesome than cougars, and were concerned for child and adult safety. More middle-aged and older participants perceived brown bears as dangerous to companion animals, and black bears as troublesome, than did younger participants, (...) and more middle-aged participants perceived brown bears as troublesome than did younger and older participants. Opinions favored trapping and removal of animals rather than shooting or toleration, but more younger participants opted for shooting, whereas more middle-aged and older participants opted for toleration and removal. Majorities agreed that the animals serve useful functions, women more than men for cougars, middle-aged more than old or young for bears, but saw only cougars as increasing their quality of life. These findings contribute to knowledge about human-wildlife relations, an important first step toward more efficient local and more general conservation policy. (shrink)

Kierkegaards deiktische Theologie wird in einer Reihe von Textinterpretationen entwickelt, die seine oft übersehenen erbaulichen Reden in einem neuen Licht präsentieren. Das Buch setzt sich mit dem traditionellen Bild der Religiosität bei Kierkegaard auseinander, wie sie in den Begriffen der Religiosität A und B zum Ausdruck kommt, und bringt neue Argumente im Sinne einer deiktischen Theologie. Sie wird in einer doppelten Perspektive entfaltet: Der Mensch richtet seinen Blick auf Gott - und Gott begegnet ihm, indem er den Menschen auf seinen (...) Nächsten hinweist. Deiktische Theologie ist weder eine Schöpfungstheologie (Religiosität A) noch eine Offenbarungstheologie (Religiosität B), sondern sie erfasst die Spannung zwischen Schöpfung und Offenbarung, die u.a. im trinitarischen Gottesbegriff begründet wird. Die Entwicklung der deiktischen Theologie Kierkegaards geschieht in der Interpretation zentraler Texte aus den erbaulichen Reden, der Einübung im Christentum sowie der Unwissenschaftlichen Nachschrift. Wichtige Themen sind darüber hinaus: die Zeitlichkeit, das Verhältnis zwischen dem Humanen und dem Christlichen, die Reue, die Sünde, das Abendmahl, das Leiden, die Nachfolge Christi, Himmelfahrt und Auferstehung. (shrink)